Implications Of Improper Protein Folding - 1595 Words

Implications of Improper Protein Folding in Alzheimer ’s Disease Stephen Sewell Schreiner University Dr. McGinnis Biochemistry Fall 2012 Abstract This paper is a brief review of the understanding of Alzheimer’s as it is generally seen today in the medical field, by scientists, physicians, and other healthcare providers alike. It examines the main hypothesis for the pathogenesis of the disease and the physical changes that the disease causes to the brain. The paper will then detail some of the treatments that are given to the patient. These include the drug related and non-drug related treatment options that are available, and discusses at what stage of the disease that they are used. Introduction Alzheimer’s disease is a neurodegenerative disorder characterized by the loss of memory and other cognitive abilities essential for the function of a healthy human being. Neuropathologically, the disease is characterized by the presence of neurofibrillary tangles and senile plaques, impaired synaptic function and cell loss.1 There is a major loss of cholinergic, noradrenergic, and dopaminergic neurons while at the same time there is an accumulation of free radicals and oxidative stress, leading to lipid peroxidation and neuronal degeneration in the tissues of the brain. Not only are there major physiological changes in patients with Alzheimer’s disease, but with these changes come cognitive symptoms as well. These include disruptions in memory, language, thinking,Show MoreRelatedSources of Ethics20199 Words   |  81 PagesETHICS: 32 Introduction: 32 HumGen: 37 Nuffield Council on Bioethics: 39 The European Union’s: 43 2.22- GENETICAL BEHAVIOR: 44 2.23- ETHICS OF BEHAVIOR HAS A BIOLOGICAL BASIS? 47 Behavioural Ethics And Genetics Study: 48 Implications of Behavioural Genetics Research In Society: 50 How the genes influence behaviour and ethics: 52 2.3- PHILOSOPHICAL: 55 2.31- Contribution Of In Ethics By The Source Of Philosophical Systems: 55 2.32- Contribution of Aristotle: 57 Read MoreAn Evaluation of an on-Farm Food Safety Program for Ontario Greenhouse Vegetable Producers; a Global Blueprint for Fruit and Vegetable Producers51659 Words   |  207 Pagesgetting pretty serious at this point. Dani has been extremely supportive and caring through this project, even on those frustrating not-so-productive days. Not once did she complain about my lack helping out around the house: skirting the laundry folding, dinner preparation and dish washing; all of which I blamed on this document. And she was always there when I needed her the most. I recently wrote in an op-ed for the International Association for Food Protection s student group that thereRead MoreDeveloping Management Skills404131 Words   |  1617 Pagesminor, it would not be likely to offend you or evoke a strong defensive reaction. That is, it would probably not require that you reexamine and change your self-concept. On the other hand, the more discrepant the information or the more serious its implications for your selfconcept, the closer it would approach your sensitive line, and you would feel a need to defend yourself against it. For example, having a coworker judge you incompetent as a manager may cross your sensitive line if you think you